PCTL, Cutaneous T-Cell Lymphoma, E7777, Clinical Trials

A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma

This study is currently recruiting participants.

The purpose of this trial is to assess the efficacy and safety of E7777 (improved purity ONTAK) in patients with persistent and recurrent cutaneous T-cell lymphoma. A lead-in dose-finding part will be used to determine the dose of E7777 that should be used to test efficacy and safety.

Study Type:  Interventional

Study Design:  

Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment

Official Title:  A Clinical Study to Demonstrate Safety and Efficacy of E7777 in Persistent or Recurrent Cutaneous T-Cell Lymphoma

Conditions: Persistent or Recurrent Cutaneous T-Cell Lymphoma

Intervention:  Drug:  E7777

Phase:  Phase 3

External Link:  https://clinicaltrials.gov/ct2/show/NCT01871727

Clinical Trials

NCT01796002

Phase 3 Multi-center Randomized Study to Compare Efficacy and Safety of Romidepsin CHOP (Ro-CHOP) Versus CHOP in Patients With Previously Untreated Peripheral T-Cell Lymphoma

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NCT01352520

SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)

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NCT01777152

ECHELON-2: A Comparison of Brentuximab Vedotin and CHP With Standard-of-care CHOP in the Treatment of Patients With CD30-positive Mature T-cell Lymphomas

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NCT01738594

Dose-Escalation Trial of Carfilzomib With and Without Romidepsin in Cutaneous T-Cell Lymphoma

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NCT01728805

Study of KW-0761 Versus Vorinostat in Relapsed/Refractory CTCL

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NCT01626664

KW-0761 or Investigator’s Choice in Subjects With Previously Treated Adult T-cell Leukemia-Lymphoma (ATL)

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NCT01660451

Open-label, Uncontrolled Phase II Trial of Intravenous P13K Inhibitor BAY80-6946 in Patients with Relapsed, Indolent or Aggressive Non-Hodgkin’s Lymphomas

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NCT01431209

Ruxolitinib Phosphate (Oral JAK Inhibitor INCB18424) in Treating Patients with Relapsed or Refractory Diffuse Large B-Cell or Peripheral T-Cell Non-Hodgkin Lymphoma

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NCT01678443

Monoclonal Antibody Therapy Before Stem Cell Transplant in Treating Patients with Relapsed or Refractory Lymphoid Malignancies

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NCT01261247

Panobinostat in Treating Patients with Relapsed or Refractory Non-Hodgkin Lymphoma

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NCT01703949

Brentuximab Vedotin in Treating Patients with Relapsed or Refractory CD30+ Lymphoma

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NCT02535247

This is a multicenter, single-arm, open label 2-stage phase 2 study exploring monotherapy with the PD-1 antibody pembrolizumab in patients with PTCL.

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NCT02168140

This trial studies the side effects and best dose of CPI-613 when given together with bendamustine hydrochloride in different conditions. 

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NCT01947140

This is a study to test how safe the combination of romidepsin and pralatrexate are in patients with lymphoid malignancies and determine dosage.

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NCT01998035

This is a dose escalation study with an initial phase 1 followed by a disease focused phase 2.  Its primary objective is to determine MTD and DLT.

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NCT02520791

This phase 1 trial studies the side effects and best dose of ICOS monoclonal antibody MEDI-570 in treating patients with PTCL follicular variant.

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NCT01431209

This phase 2 trial studies how well giving ruxolitinib phosphate works in treating patients with peripheral T-cell non-hodgkin lymphoma.

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NCT02232516

The purpose of this study is to evaluate how safe and effective the combination of romidepsin and lenalidomide is for treating patients with PTCL.

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NCT02341014

This is an open label phase 1b/2a study of patients with relapsed/refractory B- and T-cell lymphomas who are treated in a 3+3 design.

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NCT02561273

This phase 1/2 trial studies the side effects and best dose of lenalidomide when given together with combination chemotherapy in patients with NHL.

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NCT02576496

This study is to evaluate the efficacy, safety and pharmacokinetics of EDO-S101 in patients with relapsed or refractory hematologic malignancies.

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NCT02783625

The purpose of this study is to test the safety of a study drug called duvelisib.

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NCT02495415

To address the hypothesis that intermittent treatment with fenretinide intravenous emulsion will induce objective responses in patients with PTCL.

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NCT02448381

To evaluate the use of SGX301 to treat patients with patch/plaque phase cutaneous T-cell lymphoma.

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NCT02580552

This is a two-part study to evaluate the safety of MRG-106 in patients with CTCL, mycosis fungoides subtype.

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NCT02464228

This study is designed to investigate the antitumor activity of tipifarnib in subjects with advanced PTCL.

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NCT02309580

This is a Phase 1 clinical trial to find out whether ibrutinib is safe in patients with relapsed and refractory T-Cell non-Hodgkin lymphoma.

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NCT02588651

This study will include patients with MTCL that has been treated with at least one type of chemotherapy, but is not responding.

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NCT02192021

This study is to test if MNA-directed chemo-immunotherapy using doxorubicin will kill tumor cells locally to induce durable systemic immnunity. 

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NCT01902225

This is a Phase 1 efficacy study of the combination of romidepsin in combination with Doxil for adult patients with relapsed or refractory CTCL.

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NCT01738594

This randomized phase 1 trial studies the side effects and best dose of carfilzomib when given with or without romidepsin in treating CTCL.

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NCT01871727

A Trial of E7777 in Persistent and Recurrent Cutaneous T-Cell Lymphoma

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NCT02106650

This study is to evaluate the effect of leucovorin in preventing or reducing Folotyn-related Grade 3 or higher oral mucositis.

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NCT03542266

This is a phase II, multi-center study to determine the efficacy and safety of first-line CC-486 plus CHOP in patients with PTCL who have received no prior systemic therapy.

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NCT02341209

This study looks at the efficacy of Doxycycline for the treatment of Cutaneous T-cell Lymphomas.

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NCT03927105

A multicenter trial evaluating the combination of nivolumab and the antagonistic CSF-1R monoclonal antibody cabiralizumab (BMS-986227) in patients with relapsed/refractory peripheral T cell lymphoma

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NCT03586999

Patients in this study will receive nivolumab in combination with the standard of care dose-adjusted EPOCH (etoposide, prednisone, vincristine, doxorubicin, cyclophosphamide) for six 21 day cycles. 

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NCT03075553

This phase II trial studies how well nivolumab works in treating patients with peripheral T-cell lymphoma that has come back after a period of improvement or that does not respond to treatment.

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NCT03278782

This phase I/II trial studies the side effects of pembrolizumab and romidepsin and to see how well they work in treating participants with peripheral T-cell lymphoma that has come back or that does not respond to treatment. 

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NCT03598998

This phase I/II trial studies the side effects and best dose of pralatrexate when given together with pembrolizumab and how well they work in treating patients with peripheral T-cell lymphomas that has come back after a period of improvement or has not responded to treatment. 

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